Water → HCID 86622009, compound

HRID 504260Notes

Reaction equation

HRID 504260 reaction equation
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[OH:23][CH2:24][C@@H:25]([N:27]([CH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[C:46]2[N:50]([C:51]([C:64]3[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=3)([C:58]3[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=3)[C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[N:49]=[N:48][N:47]=2)=[CH:36][CH:35]=1)[C:28](=[O:32])[CH2:29][CH2:30][CH3:31])[CH3:26].O.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[CH3:26][C@H:25]([N:27]([CH2:33][C:34]1[CH:35]=[CH:36][C:37]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[C:46]2[N:50]([C:51]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)([C:64]3[CH:65]=[CH:66][CH:67]=[CH:68][CH:69]=3)[C:58]3[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=3)[N:49]=[N:48][N:47]=2)=[CH:38][CH:39]=1)[C:28](=[O:32])[CH2:29][CH2:30][CH3:31])[CH:24]=[O:23]

Participants

6

Reactant 4

HCID 962WaterHCID 24477Sodium ThiosulfateHCID 159087TriacetoxyperiodinaneHCID 66813907HCID 66813907, compound

Product 1

HCID 86622009HCID 86622009, compoundYield 82.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dess-Martin periodinane (971 mg, 2.3 mmol) was added to a solution of intermediate (5b) (474 mg, 0.8 mmol) in DCM (20 mL) at room temperature. After 30 minutes, water (20 mL) and saturated aqueous sodium thiosulfate (20 mL) was added. The mixture was extracted with DCM (3×30 mL), washed with saturated aqueous NaCl (20 mL), dried over MgSO4, and concentrated in vacuo. Silica gel chromatography gave intermediate (5c) as a white solid (411 mg).

Workup

  1. extractionThe mixture was extracted with DCM (3×30 mL)
  2. washwashed with saturated aqueous NaCl (20 mL)
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5d8d719d769a4191a47ba264927be00e
Source dataset
uspto-grants-2010_08
Patent number
US07777077B2

Reaction notes

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