Benzenepropanoic acid → Benzenepropanoyl chloride

HRID 504265Notes

Reaction equation

HRID 504265 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([CH2:11][CH2:12][C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)Cl>[C:5]1([CH2:11][CH2:12][C:13]([Cl:3])=[O:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 107Benzenepropanoic acidHCID 24386Thionyl Chloride

Product 1

HCID 64801Benzenepropanoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (21.8 mL, 300 mmol) was added to a solution of 3-phenylpropionic acid (15 g, 99.9 mol) in DCM (40 mL) and was stirred overnight. The mixture was concentrated in vacuo to yield intermediate (7a), which was used in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1406adeed3a14f5ebf210677d0bfcf8c
Source dataset
uspto-grants-2010_08
Patent number
US07777077B2

Reaction notes

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