Trifluoroacetic acid → HCID 66662243, compound

HRID 504358Notes

Reaction equation

HRID 504358 reaction equation
O[C:2]1([C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[Al]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH:4]1[CH2:5][CH:6]=[C:2]([C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[CH2:3]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 5359268AluminumHCID 59298225HCID 59298225, compound

Product 1

HCID 66662243HCID 66662243, compound

Procedure

tert-Butyl 3-hydroxy-3-(1,3-thiazol-2-yl)pyrrolidine-1-carboxylate (1.0 g, 0.0037 mol) was dissolved in trifluoroacetic acid (10.0 mL, 0.130 mol) under N2 at rt. The reaction flask was wrapped with aluminum foil and the mixture was stirred under reflux for 3 h. After cooling to rt the reaction mixture was concentrated in vacuo and used directly for the next step without further purification.

Workup

  1. temperatureunder reflux for 3 h
  2. concentrationwas concentrated in vacuo
  3. customused directly for the next step without further purification

Sources & evidence

ORD record
ord-a01ec6a991e1426cb8f88bd7680bf51e
Source dataset
uspto-grants-2010_08
Patent number
US07776874B2

Reaction notes

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