Pyridine → HCID 57750155, compound

HRID 504530Notes

Reaction equation

HRID 504530 reaction equation
[OH:1][CH2:2][C:3]1([C:8]#[N:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.N1C=CC=CC=1.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>C(Cl)Cl>[C:8]([C:3]1([CH2:2][O:1][S:22]([C:19]2[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=2)(=[O:24])=[O:23])[CH2:7][CH2:6][CH2:5][CH2:4]1)#[N:9]

Participants

5

Reactant 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 566871891-(Hydroxymethyl)cyclopentanecarbonitrile

Product 1

HCID 57750155HCID 57750155, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At 0° C., to a solution of 1-hydroxymethyl-cyclopentanecarbonitrile (10 g, 79.9 mmol) in CH2Cl2 (100 mL) was added pyridine (6.3 g, 79.9 mmol) and p-toluenesulfonyl chloride (12.18 g, 63.9 mmol). After stirred for 3 h, the solution was concentrated and the residue was used for next step reaction without further purification.

Workup

  1. concentrationthe solution was concentrated
  2. customthe residue was used for next step reaction without further purification

Sources & evidence

ORD record
ord-ffe90d2f7028486fb70e6fbb91d77abb
Source dataset
uspto-grants-2010_08
Patent number
US07776875B2

Reaction notes

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