HCID 70203590, compound → HCID 72296181, compound

HRID 504547Notes

Reaction equation

HRID 504547 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)/[C:10](=[CH:18]/[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[O:26][C:27]([C:30]([O:32][CH3:33])=[O:31])([CH3:29])[CH3:28])/[C:9]1=[O:34])=O)(C)(C)C.[F:35][C:36]1[C:41]([F:42])=[CH:40][CH:39]=[C:38]([CH3:43])[C:37]=1[CH:44]=[N:45][C:46]([O:48][Si](C)(C)C)=[CH2:47]>C1(C)C=CC=CC=1>[Cl:17][C:14]1[CH:15]=[C:16]2[NH:8][C:9](=[O:34])[C:10]3([CH:18]([C:19]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=4[O:26][C:27]([C:30]([O:32][CH3:33])=[O:31])([CH3:29])[CH3:28])[CH2:47][C:46](=[O:48])[NH:45][CH:44]3[C:37]3[C:38]([CH3:43])=[CH:39][CH:40]=[C:41]([F:42])[C:36]=3[F:35])[C:11]2=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 70203590HCID 70203590, compoundHCID 86632081HCID 86632081, compound

Product 1

HCID 72296181HCID 72296181, compoundYield 14.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a manner similar to the method described in Example 1e, E/Z-6-chloro-3-[5-chloro-2-(1-methoxycarbonyl-1-methyl-ethoxy)-benzylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (3 g, 5.94 mmol) was reacted with 1-(2,3-difluoro-6-methyl-phenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene (18 mmol) in toluene to give the title compound as a white solid (510 mg).

Sources & evidence

ORD record
ord-48d605ba1cc54632b1209b6b6d2dfd1a
Source dataset
uspto-grants-2010_08
Patent number
US07776875B2

Reaction notes

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