反应详情

A mixture of 2-(4-chloro-2-formyl-phenoxy)-butyric acid methyl ester (50 g, 0.195 mol), ethylene glycol (89 mL, 1.56 mol) and p-toluenesulfonic acid (2.8 g, 16.5 mmol) in toluene (400 mL) was refluxed with a Dean-Stark trap attached to remove the water. After 3 h, the reaction was cooled and washed with water, saturated NaHCO3 and water, dried over anhydrous Na2SO4 and concentrated to give the title compound as a light yellow oil (40 g).

1. temperaturewas refluxed with a Dean-Stark trap
2. customto remove the water
3. temperaturethe reaction was cooled
4. washwashed with water, saturated NaHCO3 and water
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated