HCID 136355274, compound → HCID 136355273, compound

HRID 504972Notes

Reaction equation

HRID 504972 reaction equation
[C:1]([N:4]([CH2:71][C:72](=[O:95])[NH:73][CH2:74][CH2:75][CH2:76][O:77][CH2:78][CH2:79][O:80][CH2:81][CH2:82][O:83][CH2:84][CH2:85][CH2:86][NH:87]C(=O)OC(C)(C)C)[CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[C:22](=[O:23])[C:21](=[O:24])[C:20]=1[NH:25][CH2:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH2:36][CH2:37][CH2:38][NH:39][C:40](=[O:70])[CH2:41][CH2:42][CH:43]([NH:47][C:48](=[O:69])[C:49]1[CH:54]=[CH:53][C:52]([NH:55][CH2:56][C:57]2[N:58]=[C:59]3[C:64](=[N:65][CH:66]=2)[N:63]=[C:62]([NH2:67])[NH:61][C:60]3=[O:68])=[CH:51][CH:50]=1)[C:44]([OH:46])=[O:45])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:1]([N:4]([CH2:71][C:72](=[O:95])[NH:73][CH2:74][CH2:75][CH2:76][O:77][CH2:78][CH2:79][O:80][CH2:81][CH2:82][O:83][CH2:84][CH2:85][CH2:86][NH2:87])[CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[C:22](=[O:23])[C:21](=[O:24])[C:20]=1[NH:25][CH2:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH2:36][CH2:37][CH2:38][NH:39][C:40](=[O:70])[CH2:41][CH2:42][CH:43]([NH:47][C:48](=[O:69])[C:49]1[CH:54]=[CH:53][C:52]([NH:55][CH2:56][C:57]2[N:58]=[C:59]3[C:64](=[N:65][CH:66]=2)[N:63]=[C:62]([NH2:67])[NH:61][C:60]3=[O:68])=[CH:51][CH:50]=1)[C:44]([OH:46])=[O:45])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 136355274HCID 136355274, compound

Product 1

HCID 136355273HCID 136355273, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

0.2 g of 1-({2-[(14-acetyl-34,34-dimethyl-16,32-dioxo-4,7,10,21,24,27,33-heptaoxa-14,17,31-triazapentatriacont-1-yl)amino]-3,4-dioxo-1-cyclobuten-1-yl}amino)-18-[(4-{[(2-amino-4-oxo-3,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid is dissolved in 2 ml of trifluoroacetic acid at ambient temperature.

Sources & evidence

ORD record
ord-930f485965704716a6b59790bb3fa73e
Source dataset
uspto-grants-2010_08
Patent number
US07780953B2

Reaction notes

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