Menthol → Ibuprofen, (+-)-

HRID 505016Notes

Reaction equation

[CH:1]1[CH:2]=[CH:3][C:4](NC2C(Cl)=CC=CC=2Cl)=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.[C:20]12(C)[C:27](C)(C)C(C[CH2:26]1)C[C:21]2=O.[CH:31]1(C)CCC(C(C)C)C(O)C1>>[OH:10][C:8]([CH:7]([C:5]1[CH:6]=[CH:1][C:2]([CH2:21][CH:20]([CH3:27])[CH3:26])=[CH:3][CH:4]=1)[CH3:31])=[O:9]

Participants

Reactant 3

HCID 1254Menthol

HCID 2537Camphor

HCID 3033Diclofenac

Product 1

HCID 3672Ibuprofen, (+-)-Yield 5%

Procedure

5% Ibuprofen cream was prepared as described in Example 2. The composition of the emulsion for 5% Diclofenac cream is presented in Table 4. The cream contains approximately 26% of the oil phase with a ratio MCT:Camphor:Menthol of approximately 4.25:1:1.

Sources & evidence

ORD record: ord-602959b2783f4b03839bcf3ac8bf415b
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07781429B2

Reaction notes

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