1-Benzyl-4-nitro-1H-imidazole → 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (1-benzyl-1H-imidazol-4-yl)-amide

HRID 505034Notes

Reaction equation

HRID 505034 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([N+:13]([O-])=O)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:16][C:17]1[CH:18]=[C:19]([CH2:24][C:25]([NH:27][CH:28]([CH2:32][CH2:33][CH3:34])[C:29](O)=[O:30])=[O:26])[CH:20]=[C:21]([F:23])[CH:22]=1>>[CH2:1]([N:8]1[CH:12]=[C:11]([NH:13][C:29](=[O:30])[CH:28]([NH:27][C:25](=[O:26])[CH2:24][C:19]2[CH:20]=[C:21]([F:23])[CH:22]=[C:17]([F:16])[CH:18]=2)[CH2:32][CH2:33][CH3:34])[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5341381-Benzyl-4-nitro-1H-imidazoleHCID 219429862-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid

Product 1

HCID 866114542-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (1-benzyl-1H-imidazol-4-yl)-amide

Procedure

1-Benzyl-4-nitro-1H-imidazole was reduced and coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound; MS 470 m/z (M+1).

Sources & evidence

ORD record
ord-d75824e4737e40bbb25cceed3636abd0
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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