Methyl (4-nitro-1-imidazolyl)acetate → (4-[2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino]-imidazol-1-yl)-acetic acid methyl ester

HRID 505035Notes

Reaction equation

HRID 505035 reaction equation
[CH3:1][O:2][C:3](=[O:13])[CH2:4][N:5]1[CH:9]=[C:8]([N+:10]([O-])=O)[N:7]=[CH:6]1.[F:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([NH:25][CH:26]([CH2:30][CH2:31][CH3:32])[C:27](O)=[O:28])=[O:24])[CH:18]=[C:19]([F:21])[CH:20]=1>>[CH3:1][O:2][C:3](=[O:13])[CH2:4][N:5]1[CH:9]=[C:8]([NH:10][C:27](=[O:28])[CH:26]([NH:25][C:23](=[O:24])[CH2:22][C:17]2[CH:18]=[C:19]([F:21])[CH:20]=[C:15]([F:14])[CH:16]=2)[CH2:30][CH2:31][CH3:32])[N:7]=[CH:6]1

Participants

3

Reactant 2

HCID 3103698Methyl (4-nitro-1-imidazolyl)acetateHCID 219429862-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid

Product 1

HCID 11582250(4-[2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino]-imidazol-1-yl)-acetic acid methyl ester

Procedure

(4-Nitro-imidazol-1-yl)-acetic acid methyl ester was reduced and coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound; MS 409.1 m/z (M+1).

Sources & evidence

ORD record
ord-2bb27ef17cb840fcaa3c1c412d5cd450
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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