2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → 1-(4-{2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester

HRID 505036Notes

Reaction equation

HRID 505036 reaction equation
[CH3:1][O:2][C:3]([C:5]1([N:9]2[CH:13]=[C:12]([N+:14]([O-])=O)[N:11]=[CH:10]2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[F:17][C:18]1[CH:19]=[C:20]([CH2:25][C:26]([NH:28][CH:29]([CH2:33][CH2:34][CH3:35])[C:30](O)=[O:31])=[O:27])[CH:21]=[C:22]([F:24])[CH:23]=1>>[CH3:1][O:2][C:3]([C:5]1([N:9]2[CH:13]=[C:12]([NH:14][C:30](=[O:31])[CH:29]([NH:28][C:26](=[O:27])[CH2:25][C:20]3[CH:21]=[C:22]([F:24])[CH:23]=[C:18]([F:17])[CH:19]=3)[CH2:33][CH2:34][CH3:35])[N:11]=[CH:10]2)[CH2:8][CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 219429862-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acidHCID 684659501-(4-Nitro-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester

Product 1

HCID 684664521-(4-{2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester

Procedure

1-(4-Nitro-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester was reduced and coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound; MS 463.0 m/z (M+1).

Sources & evidence

ORD record
ord-c708a893695d4127b11dd7baca4ec031
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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