HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → 1-(4-{2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid | HCID 21942986 | — |
| Reactant | 1-(4-Nitro-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester | HCID 68465950 | — |
| Product | 1-(4-{2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester | HCID 68466452 | — |
Reaction Steps
1-(4-Nitro-imidazol-1-yl)-cyclobutanecarboxylic acid methyl ester was reduced and coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound; MS 463.0 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781435B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-c708a893695d4127b11dd7baca4ec031 |
| Source note | uspto-grants-2010_08 |