Propanolamine ethyl ether → (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[2-(3-ethoxy-propylamino)-ethyl]-1H-imidazol-4-yl}-amide

HRID 505045Notes

Reaction equation

HRID 505045 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][CH:13]([CH2:29][CH2:30][CH3:31])[C:14]([NH:16][C:17]2[N:18]=[CH:19][N:20]([CH2:22][CH2:23]OS(C)(=O)=O)[CH:21]=2)=[O:15])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:32]([O:34][CH2:35][CH2:36][CH2:37][NH2:38])[CH3:33]>>[CH2:32]([O:34][CH2:35][CH2:36][CH2:37][NH:38][CH2:23][CH2:22][N:20]1[CH:21]=[C:17]([NH:16][C:14](=[O:15])[C@@H:13]([NH:12][C:10](=[O:11])[CH2:9][C:4]2[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=2)[CH2:29][CH2:30][CH3:31])[N:18]=[CH:19]1)[CH3:33]

Participants

3

Reactant 2

HCID 22720Propanolamine ethyl etherHCID 86600814Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester

Product 1

HCID 16004731(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[2-(3-ethoxy-propylamino)-ethyl]-1H-imidazol-4-yl}-amide

Procedure

Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester was reacted with 3-ethoxypropyl amine to provide the title compound: MS 446.2 m/z (M+1).

Sources & evidence

ORD record
ord-63b33afda08b4559b367a87bb9c444b0
Source dataset
uspto-grants-2010_08
Patent number
US07781435B2

Reaction notes

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