HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propanolamine ethyl ether → (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[2-(3-ethoxy-propylamino)-ethyl]-1H-imidazol-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propanolamine ethyl ether | HCID 22720 | — |
| Reactant | Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester | HCID 86600814 | — |
| Product | (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[2-(3-ethoxy-propylamino)-ethyl]-1H-imidazol-4-yl}-amide | HCID 16004731 | — |
Reaction Steps
Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester was reacted with 3-ethoxypropyl amine to provide the title compound: MS 446.2 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781435B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-63b33afda08b4559b367a87bb9c444b0 |
| Source note | uspto-grants-2010_08 |