HRID505048

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21112802

未命名化合物

结构：CC(c1ccc(C(F)(F)F)cc1)n1cnc([N+](=O)[O-])c1

HCID68463545

未命名化合物

PRODUCTS

生成物

结构：CCC[C@H](NC1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)c2ccc(C(F)(F)F)cc2)cn1

HCID16113572

未命名化合物

PROCEDURE

实验过程

4-Nitro-1-[1-(4-trifluoromethyl-phenyl)-ethyl]-1H-imidazole was reduced and then coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (U.S. Ser. No. 11/078,898 filed Mar. 11, 2005) to afford the title compound: MS 521.5 m/z (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-829b7c0f8cd249da9ee6b5a8787b2bd6
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07781435B2
来源说明: uspto-grants-2010_08

反应 SMILES

[N+:1]([C:4]1[N:5]=[CH:6][N:7]([CH:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH3:10])[CH:8]=1)([O-])=O.[F:21][C:22]1[CH:23]=[C:24]2[C:29](=[C:30]([F:32])[CH:31]=1)[CH2:28][CH:27]([NH:33][CH:34]([CH2:38][CH2:39][CH3:40])[C:35](O)=[O:36])[CH2:26][CH2:25]2>>[F:18][C:17]([F:20])([F:19])[C:14]1[CH:15]=[CH:16][C:11]([CH:9]([N:7]2[CH:8]=[C:4]([NH:1][C:35](=[O:36])[C@@H:34]([NH:33][CH:27]3[CH2:26][CH2:25][C:24]4[C:29](=[C:30]([F:32])[CH:31]=[C:22]([F:21])[CH:23]=4)[CH2:28]3)[CH2:38][CH2:39][CH3:40])[N:5]=[CH:6]2)[CH3:10])=[CH:12][CH:13]=1