Lithium hydroxide, monohydrate → Lithium 2-amino-6-chloronicotinate
Reaction equation
O[Li:2].O.[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>O.CO>[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O-:9])=[O:8].[Li+:2]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 70 °C
Procedure
A solution of LiOH.H2O (1.38 g, 33 mmol) in water (33 mL) was added in one portion to a suspension of methyl 2-amino-6-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL). The reaction mixture was stirred at 70° C. for 24 hours, and gradually became homogeneous. The solvents were removed under reduced pressure, and after the resulting white solid was dried under vacuum (<1 mmHg) to constant weight, 5.51 g (95%) of lithium 2-amino-6-chloronicotinate was obtained.
Workup
- customThe solvents were removed under reduced pressure
- customafter the resulting white solid was dried under vacuum (<1 mmHg) to constant weight
Sources & evidence
- ORD record
- ord-abc11101d7ea4bea821c01a30c9631ae
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07781437B2
Reaction notes
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