HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-Amino-ethyl)-2-{6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | {6-Chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid | HCID 66744257 | — |
| Product | N-(2-Amino-ethyl)-2-{6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetamide | HCID 59429635 | — |
Reaction Steps
Analogous to general procedure I, the coupling of {6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (prepared herein) with (commercially available) (2-amino-ethyl)-carbamic acid tert-butyl ester gave, after treatment with HCl and neutralisation, the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781436B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-5589a38c3630459a91a129870ed5dfa7 |
| Source note | uspto-grants-2010_08 |