Hydrochloric Acid → N-(2-Amino-ethyl)-2-{6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetamide

HRID 505116Notes

Reaction equation

HRID 505116 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([C:23]4[C:31]5[O:30][CH2:29][CH2:28][C:27]=5[CH:26]=[CH:25][CH:24]=4)[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12]([OH:14])=O)=[CH:4][CH:3]=1.C(OC(=O)[NH:38][CH2:39][CH2:40][NH2:41])(C)(C)C.Cl>>[NH2:38][CH2:39][CH2:40][NH:41][C:12](=[O:14])[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:15]([N:17]2[CH2:18][CH2:19][CH:20]([C:23]3[C:31]4[O:30][CH2:29][CH2:28][C:27]=4[CH:26]=[CH:25][CH:24]=3)[CH2:21][CH2:22]2)=[O:16])=[CH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 187201N-BOC-ethylenediamineHCID 66744257{6-Chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid

Product 1

HCID 59429635N-(2-Amino-ethyl)-2-{6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetamide

Procedure

Analogous to general procedure I, the coupling of {6-chloro-3-[4-(2,3-dihydro-benzofuran-7-yl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (prepared herein) with (commercially available) (2-amino-ethyl)-carbamic acid tert-butyl ester gave, after treatment with HCl and neutralisation, the title compound.

Workup

  1. customgave

Sources & evidence

ORD record
ord-5589a38c3630459a91a129870ed5dfa7
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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