2-Chloroethanol → 2-(4-Methylphenoxy)ethanol

HRID 50512Notes

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Cl[CH2:10][CH2:11][OH:12].[OH-].[Na+]>>[OH:12][CH2:11][CH2:10][O:7][C:6]1[CH:5]=[CH:4][C:3]([CH3:8])=[CH:2][CH:1]=1

Participants

Reactant 3

HCID 342-Chloroethanol

HCID 2879P-Cresol

HCID 14798Sodium Hydroxide

Product 1

HCID 848042-(4-Methylphenoxy)ethanol

Procedure

p-Cresol may be reacted with excess 2-chloroethanol in the presence of sodium hydroxide to give 4-(2-hydroxyethoxy)toluene which may be purified by conventional techniques.

Sources & evidence

ORD record: ord-8d0e4c3287f74fe482d5d3890498fa10
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06712893B1

Reaction notes

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