Hydrochloric Acid → HCID 16062709, compound

HRID 505122Notes

Reaction equation

HRID 505122 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([C:23]4[C:28]([O:29][CH3:30])=[CH:27][CH:26]=[CH:25][C:24]=4[O:31][CH3:32])[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12](O)=[O:13])=[CH:4][CH:3]=1.C(OC(=O)[NH:39][CH2:40][CH2:41][NH2:42])(C)(C)C.Cl>>[NH2:39][CH2:40][CH2:41][NH:42][C:12](=[O:13])[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:15]([N:17]2[CH2:18][CH2:19][CH:20]([C:23]3[C:28]([O:29][CH3:30])=[CH:27][CH:26]=[CH:25][C:24]=3[O:31][CH3:32])[CH2:21][CH2:22]2)=[O:16])=[CH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 187201N-BOC-ethylenediamineHCID 66744387{6-Chloro-3-[4-(2,6-dimethoxy-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid

Product 1

HCID 16062709HCID 16062709, compound

Procedure

Analogous to general procedure I, the coupling of {6-chloro-3-[4-(2,6-dimethoxy-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (prepared herein) with (commercially available) (2-amino-ethyl)-carbamic acid tert-butyl ester gave, after treatment with HCl and neutralisation, the title compound.

Workup

  1. customgave

Sources & evidence

ORD record
ord-12d5869642374b7596d97af1d825b1c7
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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