4-[2-(Trifluoromethyl)phenyl]piperidine → (6-Chloro-1H-indol-3-yl)-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-methanone

HRID 505126Notes

Reaction equation

HRID 505126 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22]([C:27](O)=[O:28])=[CH:23][NH:24]2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22]([C:27]([N:12]3[CH2:11][CH2:10][CH:9]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=4[C:2]([F:1])([F:15])[F:16])[CH2:14][CH2:13]3)=[O:28])=[CH:23][NH:24]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 114135584-[2-(Trifluoromethyl)phenyl]piperidineHCID 184532356-chloro-1H-indole-3-carboxylic acid

Product 1

HCID 59429661(6-Chloro-1H-indol-3-yl)-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-methanone

Procedure

Following general procedure I, the coupling of (commercially available) 4-(2-trifluoromethyl-phenyl)-piperidine (described herein) with 6-chloro-1H-indole-3-carboxylic acid gave the title compound.

Sources & evidence

ORD record
ord-93e272b46d1e42389a8ff2da02ff9713
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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