N,N-Dimethylethylenediamine → HCID 66744531, compound

HRID 505140Notes

Reaction equation

HRID 505140 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:32])([F:31])[F:30])[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12]([OH:14])=O)=[CH:4][CH:3]=1.C[N:34](C)[CH2:35][CH2:36][NH2:37]>>[ClH:1].[NH2:34][CH2:35][CH2:36][NH:37][C:12](=[O:14])[CH2:11][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:15]([N:17]2[CH2:18][CH2:19][CH:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]([F:31])([F:30])[F:32])[CH2:21][CH2:22]2)=[O:16])=[CH:7]1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 66743711HCID 66743711, compound

Product 1

HCID 66744531HCID 66744531, compound

Procedure

Analogous to general procedure I, the coupling of {6-chloro-3-[4-(2-trifluoromethyl-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (prepared herein) with (commercially available) N1,N1-dimethyl-ethane-1,2-diamine, gave the title compound.

Sources & evidence

ORD record
ord-fe8218f9f5dd45418c6f0d870831bed5
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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