tert-Butyl piperazine-1-carboxylate → Hydrochloric Acid

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl piperazine-1-carboxylate	HCID 143452	—
Reactant	{6-Chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid	HCID 66743769	—
Product	Hydrochloric Acid	HCID 313	—
Product	2-{6-Chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-1-piperazin-1-yl-ethanone hydrochloride	HCID 66743645	—

Reaction Steps

Following general procedure I, the coupling of {6-chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (preparation described herein), with (commercially available) piperazine-1-carboxylic acid tert-butyl ester gave, after treatment with HCl, gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07781436B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-2b7d5e8cd364405084e69b20fe1602b0
Source note	uspto-grants-2010_08