tert-Butyl piperazine-1-carboxylate → Hydrochloric Acid

HRID 505152Notes

Reaction equation

HRID 505152 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[F:29])[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12](O)=[O:13])=[CH:4][CH:3]=1.C(OC([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)=O)(C)(C)C>>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[F:29])[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12]([N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[O:13])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 66743769{6-Chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid

Product 2

HCID 313Hydrochloric AcidHCID 667436452-{6-Chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-1-piperazin-1-yl-ethanone hydrochloride

Procedure

Following general procedure I, the coupling of {6-chloro-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid (preparation described herein), with (commercially available) piperazine-1-carboxylic acid tert-butyl ester gave, after treatment with HCl, gave the title compound.

Workup

  1. customgave

Sources & evidence

ORD record
ord-2b7d5e8cd364405084e69b20fe1602b0
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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