HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → Carbon Dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[3,2-e]-1,2-thiazine-3-carboxamide 1,1-dioxide | HCID 54690031 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Carbon Dioxide | HCID 280 | — |
| Product | 6-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[3,2-e]-1,2-thiazine-3-carboxamide 1,1-dioxide | HCID 54690031 | — |
Reaction Steps
8 g of sodium hydrogencarbonate was dissolved in 120 g of water and mixed with a suspension of 32 g lornoxicam in 600 g of ethanol. While forming gaseous carbon dioxide, lornoxicam dissolved. 100 g of Pharmacoat 606W was added and dissolved. 212 g of sodium hydrogen carbonate was admixed and dissolved. The solution obtained was mixed with Avicel in a lab size mixer. The wet mixture was dried and then magnesium stearate and polyplasdone XL were admixed in the lab scale mixer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713089B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-935866eca8344bb5bee139d27334db8d |
| Source note | uspto-grants-2004_03 |