Sodium Bicarbonate → Carbon Dioxide

HRID 50516Notes

Reaction equation

HRID 50516 reaction equation
[C:1](=O)([O-:3])[OH:2].[Na+].[CH3:6][N:7]1[S:16](=[O:18])(=[O:17])[C:11]2[CH:12]=[C:13]([Cl:15])[S:14][C:10]=2[C:9]([OH:19])=[C:8]1[C:20]([NH:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][N:28]=1)=[O:21]>O.C(O)C>[C:1](=[O:3])=[O:2].[CH3:6][N:7]1[S:16](=[O:18])(=[O:17])[C:11]2[CH:12]=[C:13]([Cl:15])[S:14][C:10]=2[C:9]([OH:19])=[C:8]1[C:20]([NH:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][N:28]=1)=[O:21]

Participants

6

Reactant 2

HCID 516892Sodium BicarbonateHCID 546900316-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[3,2-e]-1,2-thiazine-3-carboxamide 1,1-dioxide

Product 2

HCID 280Carbon DioxideHCID 546900316-Chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[3,2-e]-1,2-thiazine-3-carboxamide 1,1-dioxide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

8 g of sodium hydrogencarbonate was dissolved in 120 g of water and mixed with a suspension of 32 g lornoxicam in 600 g of ethanol. While forming gaseous carbon dioxide, lornoxicam dissolved. 100 g of Pharmacoat 606W was added and dissolved. 212 g of sodium hydrogen carbonate was admixed and dissolved. The solution obtained was mixed with Avicel in a lab size mixer. The wet mixture was dried and then magnesium stearate and polyplasdone XL were admixed in the lab scale mixer.

Sources & evidence

ORD record
ord-935866eca8344bb5bee139d27334db8d
Source dataset
uspto-grants-2004_03
Patent number
US06713089B1

Reaction notes

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