N,N-Dimethylethylenediamine → HCID 16061513, compound

HRID 505163Notes

Reaction equation

HRID 505163 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:22][CH2:21][N:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][CH3:30])[CH2:19][CH2:18]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12]([OH:14])=O)=[CH:4][CH:3]=1.[CH3:31][N:32]([CH3:36])[CH2:33][CH2:34][NH2:35]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]([N:17]3[CH2:18][CH2:19][N:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][CH3:30])[CH2:21][CH2:22]3)=[O:16])=[CH:7][N:8]2[CH2:11][C:12]([NH:35][CH2:34][CH2:33][N:32]([CH3:36])[CH3:31])=[O:14])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 66743654HCID 66743654, compound

Product 1

HCID 16061513HCID 16061513, compound

Procedure

Analogous to general procedure I, the coupling of {6-chloro-3-[4-(2-methoxy-phenyl)-piperazine-1-carbonyl]-indol-1-yl}-acetic acid (prepared herein) with (commercially available) N1,N1-dimethyl-ethane-1,2-diamine gave the title compound.

Sources & evidence

ORD record
ord-ad523a46fed64519bb18223dbcf59a22
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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