HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 66744398, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyl 4-[2-(hydroxymethyl)phenyl]piperazine-1-carboxylate | HCID 7127802 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66744398 | HCID 66744398 | — |
Reaction Steps
A solution of (commercially available) 4-(2-hydroxymethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and (1 eq) MeI dissolved in THF was treated with NaH (2 eq) and stirred at RT for 2 h. After work-up, the crude solid was purified by SiO2 chromatography (Ethyl acetate-Heptane 1:4) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781436B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-2d97d2044bcf492d95a838659db77354 |
| Source note | uspto-grants-2010_08 |