Methyl iodide → HCID 66744398, compound

HRID 505184Notes

Reaction equation

HRID 505184 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][OH:21])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:22]I.[H-].[Na+]>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][O:21][CH3:22])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 7127802tert-Butyl 4-[2-(hydroxymethyl)phenyl]piperazine-1-carboxylate

Product 1

HCID 66744398HCID 66744398, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (commercially available) 4-(2-hydroxymethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and (1 eq) MeI dissolved in THF was treated with NaH (2 eq) and stirred at RT for 2 h. After work-up, the crude solid was purified by SiO2 chromatography (Ethyl acetate-Heptane 1:4) to give the title compound.

Workup

  1. customAfter work-up, the crude solid was purified by SiO2 chromatography (Ethyl acetate-Heptane 1:4)

Sources & evidence

ORD record
ord-2d97d2044bcf492d95a838659db77354
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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