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HRID505188

反应详情

EQUATION

反应方程式

HRID 505188 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：NCCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21
HCID16061732

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)NCCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21
HCID46898639

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone, was treated with acetylchloride (1.05 eq) and triethylamine (1.05 eq) in CH2Cl2 under argon at RT for 2 h to give after purification by prep. HPLC the title compound.

WORKUP

后处理

  1. customto give
  2. customafter purification by prep