Methyl iodide → HCID 178503342, compound

HRID 505332Notes

Reaction equation

HRID 505332 reaction equation
[CH3:1][I:2].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[S:14])[NH:8][CH:7]2[CH3:15]>CC(C)=O.C(OCC)C>[IH:2].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([S:14][CH3:1])[NH:8][CH:7]2[CH3:15]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 86608957HCID 86608957, compound

Product 1

HCID 178503342HCID 178503342, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

Methyl iodide (0.30 ml, 4.86 mmol) was added to a suspension of 6-chloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (345 mg, 1.62 mmol) in acetone (4.8 ml). The mixture was stirred for 2 hours (r.t.), diluted with diethyl ether and the title compound (538 mg, 94%) was isolated from the reaction mixture by filtration.

Sources & evidence

ORD record
ord-fe297195786f4c99aad836d48acca15c
Source dataset
uspto-grants-2010_08
Patent number
US07781441B2

Reaction notes

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