Tributylamine → HCID 178498901, compound

HRID 505366Notes

Reaction equation

HRID 505366 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:14]([O:16]C)=O)[C:10]([O:12]C)=O.[NH2:18][C:19]1[C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][NH:21][N:20]=1.C(N(CCCC)CCCC)CCC>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([OH:12])=[N:18][C:19]2[N:20]([N:21]=[CH:22][C:23]=2[C:24]([O:26][CH3:27])=[O:25])[C:14]=1[OH:16]

Participants

4

Reactant 3

HCID 7622TributylamineHCID 68679654Propanedioic acid, 2-(2,4-dichlorophenyl)-, 1,3-dimethyl esterHCID 178498890HCID 178498890, compound

Product 1

HCID 178498901HCID 178498901, compound

Conditions

Temperature
185 °C

Procedure

5.5 g of dimethyl 2-(2,4-dichlorophenyl)malonate and 2.8 g of methyl 3-aminopyrazole-4-carboxylate were mixed with 4 g of tri-n-butylamine and stirred at 185° C. for 3 h; the liberated methanol was distilled off during this operation. The mixture was then cooled and excess tri-n-butylamine was removed under reduced pressure. The resulting product was reacted crude, without further purification.

Workup

  1. distillationthe liberated methanol was distilled off during this operation
  2. temperatureThe mixture was then cooled
  3. customexcess tri-n-butylamine was removed under reduced pressure
  4. customThe resulting product was reacted crude
  5. customwithout further purification

Sources & evidence

ORD record
ord-dda59bf4248a4aa8822d7e6608195a86
Source dataset
uspto-grants-2010_08
Patent number
US07781439B2

Reaction notes

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