Hydrochloric Acid → HCID 59429711, compound

HRID 505367Notes

Reaction equation

HRID 505367 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=2[Cl:15])=[C:6]([NH:16][CH:17]([CH3:19])[CH3:18])[N:5]2[N:20]=[CH:21][C:22]([C:23]([O:25]C)=[O:24])=[C:4]2[N:3]=1.[OH-].[K+].Cl>O1CCOCC1>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=2[Cl:15])=[C:6]([NH:16][CH:17]([CH3:19])[CH3:18])[N:5]2[N:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[C:4]2[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59429712HCID 59429712, compound

Product 1

HCID 59429711HCID 59429711, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5 g of methyl 5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carboxylate were dissolved in 75 ml of 1,4-dioxane, and 75 ml of 2 N aqueous potassium hydroxide solution were added. The mixture was stirred at room temperature for 15 h (monitored by TLC) and then introduced into 1 N hydrochloric acid. The precipitated solid was filtered off with suction.

Workup

  1. filtrationThe precipitated solid was filtered off with suction

Sources & evidence

ORD record
ord-4ec704f478a14a0f9a8cde3d6b07735a
Source dataset
uspto-grants-2010_08
Patent number
US07781439B2

Reaction notes

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