Hydrochloric Acid → HCID 178428716, compound

HRID 505399Notes

Reaction equation

HRID 505399 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1.[ClH:20]>ClCCl.C(OCC)C>[ClH:20].[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178428715HCID 178428715, compound2×

Product 1

HCID 178428716HCID 178428716, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

31 mg of 2-[2-(2-Amino-4-methylpyridin-6-yl)ethyl]-3H-imidazo[4,5-b]pyridine (compound 1) are dissolved in 16 ml of dichloromethane. Under ice-cooling, 61 μl of a solution of hydrochloric acid in diethylether (2M strength) are added. The mixture is evaporated to dryness and the residue lyophilized from 15 ml water to give 35 mg of the title compound as colorless lyophilisate. M.p. 136° C. MS: 254.2 (MH+), 528.8 (2MNa+).

Workup

  1. temperatureUnder ice-cooling
  2. customThe mixture is evaporated to dryness

Sources & evidence

ORD record
ord-4ee81fb075ff48d3bccf36a697c3774c
Source dataset
uspto-grants-2010_08
Patent number
US07781453B2

Reaction notes

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