反应详情

温度

75 °C

3-chloro-5-{[5-chloro-1-(4-methoxybenzyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile (0.0097 g, 0.023 mmol) was dissolved in TFA (2 mL) and heated at 75° C. for 2 hours. The reaction mixture was then allowed to cool to room temperature and then concentrated under reduced pressure. The resulting residue was subjected to automated silica gel chromatography eluting with 0-25% ethyl acetate in hexanes to give the title product. LRMS (M+1)=304.8

1. temperatureto cool to room temperature
2. concentrationconcentrated under reduced pressure
3. washeluting with 0-25% ethyl acetate in hexanes