反应详情

To a solution of (4-mercaptophenyl)-acetic acid ethyl ester (10 g, 0.051 mol) in 150 mL of acetone is added potassium carbonate (anhydrous, 8.51 g, 0.061 mol) at 0° C., followed by dropwise addition of chloroacetone (5 mL, 0.061 mol) in 10 mL of acetone at 0° C. The reaction is then maintained at RT for 2 h. The reaction is filtered and the filtrate is concentrated under vacuum. The residue thus obtained is diluted with 15 mL of water and extracted with ethyl acetate (2×50 mL). The organic layer is then washed with water and brine, dried over sodium sulfate, filtered and evaporated under vacuum to give [4-(2-oxo-propylsulfanyl)-phenyl]-acetic acid ethyl ester as a yellow oil.

1. filtrationThe reaction is filtered
2. concentrationthe filtrate is concentrated under vacuum
3. customThe residue thus obtained
4. extractionextracted with ethyl acetate (2×50 mL)
5. washThe organic layer is then washed with water and brine
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customevaporated under vacuum