反应详情

A mixture of Na2CO3 (4.74 g, 44.72 mmol) and 3-formylphenylboronic acid (3.40 g, 22.67 mmol) in water (15 mL) were added to a solution of 2-bromopyrimidine (3.00 g, 18.87 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.72 g, 0.62 mmol) in DME (30 mL) and the mixture was heated to reflux for 24 h. The cooled reaction mixture was diluted with dichloromethane, washed with sat. aq. NaHCO3 and brine, dried (MgSO4), and concentrated. Purification by chromatography (SiO2, 1:1 hexane/ethyl acetate) yielded 2.20 g (63%) of the title compound. MS 185 (M+H)+.

1. temperaturethe mixture was heated
2. temperatureto reflux for 24 h
3. customThe cooled reaction mixture
4. washwashed with sat. aq. NaHCO3 and brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customPurification by chromatography (SiO2, 1:1 hexane/ethyl acetate)