反应详情

20.0 g (0.143 mol) of 5-fluoro-2-hydroxybenzaldehyde are dissolved in 250 ml of acetonitrile. 81.04 g (0.57 mol) of iodomethane and 39.5 g (285 mol) of potassium carbonate are added, and the suspension is heated at reflux for 3 hours. The suspension is filtered and the mother liquor is diluted with ethyl acetate, washed twice with water, dried over magnesium sulphate and filtered, and the solvents are evaporated under reduced pressure.

1. temperaturethe suspension is heated
2. temperatureat reflux for 3 hours
3. filtrationThe suspension is filtered
4. additionthe mother liquor is diluted with ethyl acetate
5. washwashed twice with water
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customthe solvents are evaporated under reduced pressure