反应详情

19.0 g (0.12 mol) of (5-fluoro-2-methoxyphenyl)methanol are dissolved in 105 ml of dichloromethane. One drop of DMF is added, and 26.6 ml (0.37 mol) of thionyl chloride are then added slowly. The solution is stirred at RT for 2 hours and evaporated under reduced pressure. The residue is taken up in ethyl acetate, the mixture is cooled and admixed with water and then washed with saturated sodium bicarbonate solution and water, dried over magnesium sulphate and evaporated under reduced pressure.

1. customevaporated under reduced pressure
2. temperaturethe mixture is cooled
3. washwashed with saturated sodium bicarbonate solution and water
4. dry with materialdried over magnesium sulphate
5. customevaporated under reduced pressure