反应详情

温度

80 °C

To di t-butylcarbonate (32.29 g, 147.95 mmol) was added hexane (35 ml) and the solution was refluxed under heating at 80° C. Under refluxing, 2-amino-3-methylpyridine (10.00 g, 92.47 mmol) in ethyl acetate (10 ml) was dropped in a period of 15 minutes. After the mixture was refluxed for 2 hours and cooled to room temperature, thereto was added hexane (20 ml). The resulting crystals were filtered and dried in vacuo to give the subject compound (12.39 g, 64%).

1. temperaturethe solution was refluxed
2. temperatureUnder refluxing
3. temperatureAfter the mixture was refluxed for 2 hours
4. temperaturecooled to room temperature
5. filtrationThe resulting crystals were filtered
6. customdried in vacuo