2-Chloro-3-nitropyridine → HCID 68464299, compound

A solution of 2-chloro-3-nitropyridine (4.76 g, 30.0 mmol) in THF (50 ml) was stirred at −70° C. and therein was dropped in a period of 40 minutes vinyl magnesium bromide (1.0 M in THF, 80.0 ml, 80.0 mmol). The mixture was warmed to room temperature and stirred over night. The reaction mixture was quenched with aqueous ammonium solution, made alkaline with aqueous sodium bicarbonate solution and extracted with chloroform. The organic layer was washed with water, dried over magnesium sulfate and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography. Thus obtained compound was dissolved in methanol (20 ml), and thereto was added 10% palladium hydroxide-carbon (50% wet)(40 mg). The mixture was stirred at room temperature under a hydrogen atmosphere at ordinary pressure for 5 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give the subject compound (595 mg, 13%).

1. customThe reaction mixture was quenched with aqueous ammonium solution
2. extractionextracted with chloroform
3. washThe organic layer was washed with water
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customThe solvent was removed in vacuo
7. customthe residue was purified by silica gel column chromatography
8. dissolutionThus obtained compound was dissolved in methanol (20 ml)
9. additionwas added 10% palladium hydroxide-carbon (50% wet)(40 mg)
10. stirringThe mixture was stirred at room temperature under a hydrogen atmosphere at ordinary pressure for 5 hours
11. filtrationThe reaction mixture was filtered through Celite
12. concentrationthe filtrate was concentrated in vacuo

ORD record

ord-ed74192d062747a5b63340570467845a

Source dataset

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07781479B2