Methanol → HCID 59430736, compound

HRID 505682Notes

Reaction equation

HRID 505682 reaction equation
[CH3:1][C:2]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]\[CH2:17][N:18]2[CH:22]=[CH:21][CH:20]=[C:19]2[C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)=[CH:11][CH:10]=1)([CH3:6])[C:3]([OH:5])=[O:4].[OH-].[Na+:33].CO>>[CH3:6][C:2]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]\[CH2:17][N:18]2[CH:22]=[CH:21][CH:20]=[C:19]2[C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)=[CH:11][CH:10]=1)([CH3:1])[C:3]([O-:5])=[O:4].[Na+:33]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 59430737HCID 59430737, compound

Product 1

HCID 59430736HCID 59430736, compound

Procedure

To the compound of Example 1-2 (384 mg, 0.92 mmol) was added sodium hydroxide in methanol (0.1 mol/l, 9.2 ml, 0.92 mmol) and the solvent was removed in vacuo. The residue was subjected to azeotropic distillation with diethyl ether to give the subject compound (quant.).

Workup

  1. customthe solvent was removed in vacuo
  2. distillationThe residue was subjected to azeotropic distillation with diethyl ether
  3. customto give the subject compound (quant.)

Sources & evidence

ORD record
ord-6ec837cfa431425bbb09b9526f024122
Source dataset
uspto-grants-2010_08
Patent number
US07781479B2

Reaction notes

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