4-Methoxybenzyl alcohol → (+/-)-(3SR,3aRS)-4-methoxybenzyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylate
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH:18]([CH:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:17]3[C:12]([C:13]4[CH:27]=[CH:26][C:25]([C:28]([OH:30])=[O:29])=[CH:24][C:14]=4[CH2:15][CH2:16]3)=[N:11]2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[CH3:31][O:32][C:33]1[CH:34]=[CH:35][C:36]([CH2:39]O)=[CH:37][CH:38]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH:18]([CH:19]3[CH2:20][CH2:21][CH2:22][CH2:23]3)[CH:17]3[C:12]([C:13]4[CH:27]=[CH:26][C:25]([C:28]([O:30][CH2:39][C:36]5[CH:35]=[CH:34][C:33]([O:32][CH3:31])=[CH:38][CH:37]=5)=[O:29])=[CH:24][C:14]=4[CH2:15][CH2:16]3)=[N:11]2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared according to Method E from (±)-(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid, Example 15 and p-methoxybenzyl alcohol. Yellow solid, 194 mg. ES-MS m/z 540 (M+H).
Sources & evidence
- ORD record
- ord-368d9241805c41dea137a7b92bca4e06
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07781428B2
Reaction notes
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