2-(Trimethylsilyl)ethanol → HCID 68799332, compound

HRID 505772Notes

Reaction equation

HRID 505772 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH:18]([CH:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:17]3[C:12]([C:13]4[CH:27]=[CH:26][C:25]([C:28]([OH:30])=[O:29])=[CH:24][C:14]=4[CH2:15][CH2:16]3)=[N:11]2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[CH3:31][Si:32]([CH3:37])([CH3:36])[CH2:33][CH2:34]O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH:18]([CH:19]3[CH2:20][CH2:21][CH2:22][CH2:23]3)[CH:17]3[C:12]([C:13]4[CH:27]=[CH:26][C:25]([C:28]([O:30][CH2:34][CH2:33][Si:32]([CH3:37])([CH3:36])[CH3:31])=[O:29])=[CH:24][C:14]=4[CH2:15][CH2:16]3)=[N:11]2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 180132-(Trimethylsilyl)ethanolHCID 24983760(+/-)(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid

Product 1

HCID 68799332HCID 68799332, compound

Procedure

The title compound was prepared according to Method E from (±)-(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid, Example 15 and 2-(trimethylsilyl)ethanol. Yellow solid, 192 mg. ES-MS m/z 520 (M+H).

Sources & evidence

ORD record
ord-aed504ef4df64431b59d3e8819d5e49d
Source dataset
uspto-grants-2010_08
Patent number
US07781428B2

Reaction notes

Loading…