反应详情

A solution (0.3 M) of ethyl 4-[(tert-butoxycarbonyl)amino]-5-[(trimethylsilyl)ethynyl]thiophene-2-carboxylate in THF was treated with n-Bu4NF (2 eq.). The mixture was irradiated in a microwave apparatus at 120° C. for 20 min. Evaporation of the solvent gave a residue that was purified by flash chromatography on silica gel (1:3 AcOEt/petroleum ether) to afford the title compound (94%) as a solid.

1. customThe mixture was irradiated in a microwave apparatus at 120° C. for 20 min
2. customEvaporation of the solvent
3. customgave a residue that
4. customwas purified by flash chromatography on silica gel (1:3 AcOEt/petroleum ether)