HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | ethyl 4H-thieno[3,2-b]pyrrole-2-carboxylate | HCID 25258328 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid | HCID 58679083 | 98% |
Reaction Steps
A solution (0.25 M) of ethyl 4H-thieno[3,2-b]pyrrole-2-carboxylate in EtOH was treated with cyclohexanone (2 eq.) and sodium ethoxide (2.05 eq.) then heated to reflux for 4 h. After cooling down, it was acidified with aqueous HCl (6 N) and the precipitate was filtered and dried, affording the title compound (98%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781431B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-3ce9577b9f8743c7af7f1fde928b1060 |
| Source note | uspto-grants-2010_08 |