反应详情

A solution (0.25 M) of ethyl 4H-thieno[3,2-b]pyrrole-2-carboxylate in EtOH was treated with cyclohexanone (2 eq.) and sodium ethoxide (2.05 eq.) then heated to reflux for 4 h. After cooling down, it was acidified with aqueous HCl (6 N) and the precipitate was filtered and dried, affording the title compound (98%) as a solid.

1. temperaturethen heated
2. temperatureto reflux for 4 h
3. temperatureAfter cooling down
4. filtrationthe precipitate was filtered
5. customdried