Methyl morpholine oxide → 1-benzyl-2-chloro-5-phenyl-1H-pyrrole-3-carbaldehyde

Participants

Reaction Steps

A solution (0.1 M) of (1-benzyl-2-chloro-5-phenyl-1H-pyrrol-3-yl)methanol in DCM at 0° C. was treated with N-methylmorpholine oxide (1.5 eq.) and TPAP (0.05 eq.). The mixture was stirred at RT for 1 h then it was filtered through a pad of silica gel and washed with DCM. The combined organic phase was concentrated affording the title compound (77%) as an oil.

Provenance & Evidence