Hydrochloric Acid → 3-(Piperidin-4-ylmethyl)oxazolidine-2,4-dione hydrochloride

HRID 505869노트

반응식

HRID 505869 반응식
[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[C:5](=[O:21])[CH2:4][O:3]1.[ClH:22]>O1CCOCC1.C(O)(C)C>[ClH:22].[NH:11]1[CH2:12][CH2:13][CH:8]([CH2:7][N:6]2[C:5](=[O:21])[CH2:4][O:3][C:2]2=[O:1])[CH2:9][CH2:10]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 684647311,1-Dimethylethyl 4-[(2,4-dioxo-1,3-oxazolidin-3-yl)methyl]piperidine-1-carboxylate

생성물 1

HCID 684627993-(Piperidin-4-ylmethyl)oxazolidine-2,4-dione hydrochloride

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 312751,4-Dioxane용매

실험 절차

A suspension of 12.51 g (41.95 mmol) of 1,1-dimethylethyl 4-[(2,4-dioxo-1,3-oxazolidin-3-yl)methyl]piperidine-1-carboxylate, obtained in step 2.2., in 65 ml of dioxane is admixed with 38.10 ml (209.75 mmol) of a solution of hydrochloric acid (5N) in isopropanol. Stirring is continued at approximately 60° C. for 17 hours. The suspension is allowed to return to ambient temperature. The solid formed is collected by filtration and then washed repeatedly with ether and dried under vacuum at approximately 70° C.

후처리

  1. customobtained in step 2.2
  2. customto return to ambient temperature
  3. customThe solid formed
  4. filtrationis collected by filtration
  5. washwashed repeatedly with ether
  6. customdried under vacuum at approximately 70° C.

출처 및 근거

ORD 기록
ord-ab6b0f02470d4b529e912d5fee11fab0
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781590B2

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