反应详情

1-Acetyl-6-iodoindoline (1.06 g, 3.7 mmol), NaOH (1.16 g, 29 mmol), EtOH (8 mL), and H2O (6 mL) are heated at 90° C. overnight. The reaction mixture is then partitioned between H2O and EtOAc. The organic layer is extracted into aqueous HCl. The aqueous layer is in turn basified with NaOH, and is extracted with EtOAc. The organic layer is dried and concentrated. Hexane trituration yields 6-iodoindoline (577 mg, 64%) as a brown solid.

1. customThe reaction mixture is then partitioned between H2O and EtOAc
2. extractionThe organic layer is extracted into aqueous HCl
3. extractionis extracted with EtOAc
4. customThe organic layer is dried
5. concentrationconcentrated